The pop stars are leading the field ahead of the awards show in November with nods in categories including Best Pop, Best Female and Best Song - and they will compete against Rihanna in all three categories.
Miley Cyrus and Usher join the trio in the Best Pop category, while Shakira and Cyrus are also up for Best Female.
The Best Song prize will be a competition between Gaga's Bad Romance, Perry's California Gurls and Usher's Omg, while Rihanna features twice with Rude Boy and her Eminem collaboration Love the Way You Lie. The pair's rap collaboration will also go up against Gaga's Telephone and Perry's California Gurls in the Best Video category, along with Thirty Seconds to Mars' Kings and Queens and
Plan B's Prayin'.
Gaga will take on her rock contemporaries in the Best Live act category - going up against Bon Jovi, Muse; Kings of Leon and Linkin Park, while in the Best Rock category Kings of Leon, Muse and Linkin Park will fight it out with Thirty Seconds To Mars and Ozzy Osbourne.
For the Best Male honour, Justin Bieber is nominated alongside his hero Kanye West, as well as Eminem, Usher and Enrique Iglesias, while the teen star will also compete for the Best New Act honour along with Ke$ha, B.o.B., Jason Derulo and Plan B.
The awards will be handed out at a ceremony in Madrid, Spain on 7 November.
Nominations:
Best Female
Best Live Act
Best Pop
Best Song: Bad Romance
Best Video: Telephone
Teen Music
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